▶️ Registration:
https://forms.gle/GjxvRc5AgQXYqPey7
As the limitation of the space, please reserve your spot as soon as possible.
▶️ Time:
2023-04-29 (Sat) 2:00 pm - 3:30 pm (ET)
▶️ Place:
BioLabs Lecture Hall 1080, (Bri Biological Labs, 16 Divinity Ave, Cambridge, MA 02138)
▶️ Remote join through Zoom:
The link for the zoom participants will be provided at the end of the registration form.
▶️ Event agenda: (ET):
2:00 pm - 3:00 pm Talk "Exploring the Landscape of Functional Proteins by Computational Design"
3:00 pm - 3:30 pm Fireside Chat with Industry Expert
3:30 pm - 4:00 pm Network Session
▶️ Speaker:
Speaker:
◆ Bruno Correia
Associate Professor, Lab of Protein Design and Immunoengineering, EPFL
Grass Fellow, Harvard Radcliffe Institute
Bruno Correia joined the École Polytechnique Fédérale de Lausanne (EPFL) as an assistant professor in 2015. Very early in his scientific career he found out his fascination about protein structure and function. His PhD studies evolved in the direction of immunogen design and vaccine engineering which sparked his interest in the many needs and opportunities in vaccinology and translational research. His efforts resulted in an enlightening piece of work where for the first time, computationally designed immunogens elicited potent neutralizing antibodies. During his postdoctoral studies he joined a chemical biology laboratory at the Scripps Research Institute. In this stage he developed novel chemoproteomics methods for the identification of protein-small molecule interaction sites in complex proteomes. His research group focuses on developing computational tools for protein design with particular emphasis on applying these strategies to immunoengineering, e.g., vaccine and cancer immunotherapy. Recently, his lab introduced novel ways of describing protein molecules based on surfaces’ chemical and geometrical features.
Fireside Chat Panelist:
◆ Ching-Lin Hsieh
Principal Scientist, SANOFI Vaccine R&D
Dr. Ching-Lin Hsieh is currently a principal scientist at SANOFI. He earned his PhD in Comparative Biomedical Sciences in Cornell University with research focus on pathogenesis of Leptospirosis, a zoonotic disease caused by a spirochete. He then utilized the structure-based design method and designed pre-fusion stabilized SARS-CoV-2 spike protein with higher yield and temperature stability that is more feasible for vaccine development with Dr. Jason McLellan during his postdoc. His area of expertise pertains to the mechanisms of bacterial adhesion and immune evasion. In addition, he is specialized in protein engineering particularly for structure-guided vaccine design of pre-fusion stabilized coronavirus spike proteins, RSV, hMPV, PIV fusion proteins as well as flu HA proteins.
▶️ Moderator:
◆ Chun-Chen Jerry Yao
PhD student in Dana-Farber Cancer Institute and Department of Molecular and Cellular Biology, Harvard University
Jerry is a graduate student in Harvard’s Molecules, Cells, and Organisms (MCO) program. He earned his BSc at MIT in Brain and Cognitive Science (BCS), where he optimized an in situ sequencing-by-synthesis method in Ed Boyden’s lab and Fei Chen’s lab; he also studied transcription-translation uncoupling in Bacillus subtilis in Gene-Wei Li’s lab. During his gap year before starting at Harvard, he served the Taiwanese army and then worked with Dan Tawfik at the Weizmann Institute to investigate the origin of peptides and the genetic code in the origin of life. For his PhD, he hopes to elucidate the principles of biomolecular evolution of enzyme specificity using protein design, evolutionary biology, and high-throughput experimental approaches.
▶️ Event agenda: (ET):
2:00 pm - 3:00 pm Talk "Exploring the Landscape of Functional Proteins by Computational Design"
3:00 pm - 3:30 pm Fireside Chat with Industry Expert
3:30 pm - 4:00 pm Network Session
