The Department of Energy Systems Biology Knowledgebase (KBase; http://kbase.us) is a knowledge creation and discovery environment designed for both biologists and bioinformaticians. KBase integrates a variety of data and analysis tools, from DOE and other public services, into an easy-to-use platform that leverages scalable computing infrastructure to perform sophisticated systems biology analyses. KBase is freely available and a developer extensible platform enabling scientists to analyze their own data within the context of public data and share findings across the system.

We believe KBase can serve the ISSB community-at-large as it provides an extensible range of integrated biological data types and associated analytical tools (Apps) presently including gene expression and transcriptomics analysis, comparative genomics, genome annotation, metabolic simulation, and visualization. Over 200 Apps are now available in KBase (https://kbase.us/applist/), supporting over 7000 users on their analysis and publications (https://kbase.us/publications/). These Apps can be applied to microbes, plants and their communities.