Clinical Neuropathology QUIZ #17

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Published in Clinical Neuropathology Vol 42 nr.1 (January- February 2023). Based on papers and editorial of Clinical Neuropathology of the same issue: https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-42-2023/issue/januaryfebruary-11.html

1. Which of the following is the most common localization of astroblastoma?

1 point

a - brainstem

b - cerebellum

c - basal ganglia

d - cerebral hemispheres

e - spinal cord

2. Which of the following genetic alterations is typical for astroblastoma?

1 point

a - H3K27 alteration

b - MN1 alteration

c - YAP1 fusion

d - FOXR2 activation

e - MYCN amplification

3. Astroblastoma corresponds to which of the following CNS-WHO Grades?

1 point

a - Grade 1

b - Grade 2

c - Grade 3

d - Grade 4

e - no CHS-WHO Grade has been defined to date

4. Cowdry Type A inclusion bodies may be seen in which of the following infectious diseases?

1 point

a - HSV

b - VZV

c - Measles

d - all of the above

5. Which of the following has been reported to occur as a complication of vaccination?

1 point

a - measles inclusion body encephalitis

b - rubella encephalitis

c - subacute sclerosing panencephalitis

d - Herpes encephalitis

e - Tick-Borne encephalitis

6. Which of the following are potential fields of application of Raman spectrocopy?

1 point

a - intraoperative assessment of resection margins

b - intraoperative identification of tumor tissue

c - prediction of molecular alterations based on Raman spectra

d - screening of biofluids for the presence of certain disease

e - all of the above

7. Hyphal-like structures mimicking actinomycosis have been reported in which of the following Cysts?

1 point

a - arachnoid cysts

b - Rathke cysts

c - Pars intermedia cysts

d - colloid cysts

e - epidermoid cysts

8. Which of the following immunohistochemical stains is typically positive in astroblastoma?

1 point

a - IDH1

b - BRAF (V600E)

c - NeuN

d - H3K27M

e - GFAP

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