The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a revolutionary gene-editing technology that has transformed the landscape of biological research and medical interventions.  It was initially discovered in the genomes of bacteria as an adaptive immune response mechanism.  With the better understanding of CRISPR technologies to-date, scientists harnessed the endonuclease activity of the Cas endonucleases into the system to edit specific DNA sequences.

The applications of CRISPR technology have been ground-breaking and extensive.  In the field of molecular biology research, CRISPR has enabled precise genome editing, allowing scientists to study the gene functions, regulations and interactions leading to significant advancements in our understanding of genetics and disease mechanisms.  With the optimization of CRISPR technology, it has been applied to various applications for different purposes, including the medicine for novel treatments and therapies development, the agriculture and biotechnology to increase yield and pest resistant. 

In conclusions, CRISPR’s journey from a bacterial defense mechanism to a versatile gene-editing tool has revolutionized the life sciences.  As a key service provides in CRISPR, IDT offers a one-stop solutions of CRISPR to help accelerating and simplifying the entire genome editing workflow.  Today’s presentations will cover several key highlights, including:

1)     Brief overview about CRISPR

2)     IDT solutions for CRISPR

3)     IDT novel development to improve the knock-in HDR efficiency