東京大学 竹内研究室主催で、下記のオンラインセミナーを開催いたします。奮ってご参加ください。なお、本セミナーは、新学術領域「情報物理学でひもとく生命の秩序と設計原理」が主催するIPBセミナーシリーズの一環として、共同開催となります。セミナーは英語で行われます。
セキュリティの都合上、事前登録をお願いしておりますので、参加をご希望の方は本フォームにて登録をお願いいたします。
The following online seminar will be held, organized by Takeuchi Lab (Univ. Tokyo) and jointly by Grant-in-Aid for Innovative Areas "Information physics of living matters" (IPB seminar series). The seminar will be given in English. For the sake of security, please register on this page beforehand to participate in the seminar.
Speaker:
Dr. Tetsuya Hiraiwa,
Mechanobiology Institute, National University of Singapore, Singapore
e-mail:
mbithi@nus.edu.sgTitle:
Dynamic self-organization and collective chemotaxis of migrating cells through contact communication
Abstract:
Migration is a ubiquitous kind of eukaryotic cell behavior. Some cells migrate around on a substrate according to intracellular signals that localize at their front or back, even without extracellular cues. In light of this, we theoretically investigated single eukaryotic cell migration with such intrinsic polarity [1,2] and recently applied the theory to the multicellular case where cells communicate with each other [3,4,5].
In this talk, I will address what forms of multicellular dynamic patterns, or dynamic self-organization, can be formed through intercellular contact communication of migrating cells. I plan to explain the concept and the results of our numerical simulations based on an individual cell-based model in which migrating cells perform contact following and inhibition/attraction of locomotion [3,5]. In particular, I would like to present the results showing that (i) tuning those strengths causes varieties of dynamic self-organization, and (ii) this includes a novel form of collective migration, snake-like dynamic assembly [5]. I will compare some of our results with experimental observations of a social cellular slime mold, Dictyosteloum discoideum, and its mutant, showing the traveling density wave formation [4]. I may also talk about how such dynamic self-organization can contribute to the accuracy of taxis behaviour in population [3,5].
[1] T. Hiraiwa et al., “Relevance of intracellular polarity to accuracy of eukaryotic chemotaxis” Physical Biology 11, 056002 (2014).
[2] T. Hiraiwa, A. Baba and T. Shibata, “Theoretical model for cell migration with gradient sensing and shape deformation” Euro. Phys. J. E 36, 32 (2013).
[3] T. Hiraiwa, “Two types of exclusion interactions for self-propelled objects and collective motion induced by their combination” Phys. Rev. E 99, 012614 (2019).
[4] M. Hayakawa, T. Hiraiwa, Y. Wada, H. Kuwayama and T. Shibata, “Polar pattern formation induced by contact following locomotion in a multicellular system” eLife 9: e53609 (2020).
[5] T. Hiraiwa, “Dynamic self-organization of idealized migrating cells by contact communication”, Phys. Rev. Lett. 125, 268104 (2020).