COS597N MLSB Week 4 Pre-lecture Questions
Readings:
1. Zhong et al. Reconstructing continuous distributions of protein structure from cryo-EM images. ICLR 2020 Spotlight.
2. Zhong et al. CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks. Nature Methods 2021.

Due before class on 9/28
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Q1: Name two ways cryoDRGN differs from previous approaches
Q2: What is the Fourier slice theorem? How is it used in cryoDRGN?
Q3: What is Fourier Shell Correlation? How is it used as a metric in Table 2 of Zhong et al ICLR 2020?
Q4: What assumptions does the cryoDRGN model make about the underlying data?
Q5: How are cryo-EM reconstruction methods validated?
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