Second Sessional Exam: Medicinal Chemistry 1

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Marks Distribution
MCQs: 20M
True or False: 05M
Match the Pairs: 05M
Total : 30M

Name of Student *

Roll no. *

Prn no. *

1. All neuroleptics except ………….. have antiemetic action. *

1 point

a. Chlorpromazine

b. Haloperidol

c. Thioridazine

d. Triflupromazine

2. Acetophenone, formaldhyde and tetrahydro pyrrolidine on mannich condensation gives *

1 point

Ipratropium

Pilocarpine

Phencyclidine

Procyclidine

3. Following are synthetic anticholinergics except…….. *

1 point

Glycopyrolate

Orphenadrine citrate

Tropicamide

None of the above

4. Benzodiazepines act by following mechanism *

1 point

Decrease chloride conductance and produce depolarization

Increase chloride conductance and produce hyperpolarization

Increase chloride conductance and produce depolarization

Decrease chloride conductance and produce hyperpolarization

5. ............ seizure is charcterized by sudden loss of muscle tone. *

1 point

Myoclonic

Atonic

Tonic- Clonic

Absence

6. Following is not a side effect of anticholinergic *

1 point

Dryness

Anorexia

Blurry vision

Diarrohea

7. Following drugs find use as insecticide *

1 point

Parathion

Malathion

Both of above

None of above

8. Generic name of (–) hyoscine is *

1 point

Atropine

Scopolamine

Hyoscyamine

Tropine

9. Acetylcholine is synthesized from *

1 point

D - Serine

D -Tryptophan

D - Tyrosine

None of the above

10. 2’ chloro substituted analog of oxaxepam is *

1 point

Diazepam

Chlorazepate

Lorazepam

Chlorazepam

11. Identify inhibitory muscarinic receptor *

1 point

12. What is not true about clozapine. *

1 point

It is a atypical antipsychotic.

It does not blocks D2 recptors

It is dibenzodiazepine

None of the above

13. A __________ is drugs that are intended to produce sleep by depressing CNS *

1 point

Sedatives

Analgesics

Hypnotics

Anxiolytics

14. What is not true about edrophonium chloride. *

1 point

It has more rapid onset of action than neostigmine

It is used in treatment of arrhythmia

It is used in treatment of myasthenia gravis

None of the above

15. Following group is essential for anticholinergic activity. *

1 point

Tertiary amine

Quarternary amine

Primary amine

Unsubstituted amino group.

16. ……….. alkaloid is obtained from calabar beans *

1 point

Physostigmine

Neostigmine

Pilocarpine

Pyridostigmine

17. The quarternary anlogues of belladonna alkaloids are preferred over natural alkaloids for antisecretory/antispasmodic activity because *

1 point

They have additional nicotinic receptor blocking activity

They are incompletely absorbed after oral ingestion.

They are devoid of CNS and ocular effects.

They are more potent than atropine

18. Parasympathetic system does not produces following effect *

1 point

Relaxes rectum

Increase Saliva

Increase in heart rate

Pupil constriction

19. Which of the following drug is a “typical” antipsychotics *

1 point

Chlorpromazine

Olanzepine

Clozapine

Quetiapine

20. The correct IUPAC nomenclature of diazepam is *

1 point

7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepine-2-one

8-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepine-2-one

7-Chloro-1,3-dihydro-1-methyl-5(2-chloro)phenyl-2H-1,4-benzodiazepine-2-one

7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-one

Option 5

21. Anticholinergics produce contraction of sphincter *

1 point

True

False

22. Sedative and hypnotic activity cannot reside in same drug *

1 point

True

False

23. Paramethadione can cause fetal trimethadione syndrome *

1 point

TRUE

False

24. Pralidoxime is a anticholinergic drug *

1 point

True

False

25. Cholinergic drugs bind to alpha and beta receptors *

1 point

True

False

5 points

Chlorpromazine

Phenytoin

Haloperidol

Carbachol

Diazepam

Benzodiazepine

Phenothiazine

Butyrophenone

Choline ester

Hydantoin

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