QUIZ (Plenary Lectures)

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Quiz questions as submitted by Plenary Lecturers

Brain tumor diagnosis in transition - from single parameter analyses to multi-omics (Plenary 1)

1) Which statements to Omics data are correct? 1) OMICS platforms provide more answers than questions asked; 2) RNA-sequencing cannot be performed from FFPE-tissue; 3) DNA sequencing addresses the phosphorylation status of signal transduction relevant proteins; 4) Copy number profiles tend to gain alterations during tumour progression *

1 point

2) and 3)

1) and 4)

All of the above

None

2) Methylation based classification of brain tumours relies on?

1 point

A) The transformation of morphological features to molecular parameters

B) The fact, that CpG methylation accelerates and expands during tumour development

C) The relative stability of differentiation specific methylation patterns throughout tumour progression D. the benefits of methyl- opposed to that of ethyl-alcohol

Clear selection

Lessons learned from brain banking for neurodegenerative diseases (Plenary 2)

3) Brain banking of human aging and neurodegenerative diseases contributes to scientific discovery by which of the following? *

1 point

A) Providing samples for whole genome sequencing.

B) Performing hierarchical cluster analyses.

C) Biochemical purification of brain proteins.

D) Pattern recognition based upon MRS.

4) How do quantitative approaches in human neuropathology provide value beyond diagnostic categorization? *

1 point

A) Plaque and tangle counts can predict underlying genetic risk factors.

B) Lewy body counts in specific brain regions correlate with clinical features.

C) Semi-quantitative scores for glial lesions in tauopathies can be used for differential diagnosis.

D) Scoring the severity of amyloid angiopathy in a single brain region can predict overall cerebrovascular burden.

Brain somatic mutations in focal cortical dysplasias (Plenary 3)

5) The variant allele frequency (or mosaic rate) typically observed in FCD is: *

1 point

A) 1%

B) 5%

C) 20%

D) 50%

6) Brain somatic mutations can be detected in: *

1 point

A) Blood-derived DNA

B) Cell-free DNA from CSF

C) Fibroblasts

D) Nasal-swab

The invasive behavior of glioma cells in the CNS and their biological characteristics (Plenary 4)

7) Which of the following statements are correct?

1 point

A) Gliomas never form extracranial metastases

B) Circulating tumor cells from gliomas are rare since the blood-brain barrier prevents the cells from entering the circulation

C) Single tumor cell invasion from gliomas into the brain parenchyma is characterized by a specific cellular phenotype

D) Invasive glioma cells show an extensive cellular plasticity mediated by the host microenvironment

Clear selection

Polyglucosan storage in muscle and brain - disease entities and pathogenesis (Plenary 5)

8) Which of the following glycogenoses is associated with polyglucosan bodies? *

1 point

A) GSD0

B) GSD1

C) GSD2

D) GSD3

E) GSD4

9) Defects in which of the following protein modifications is common in polyglucosan storage diseases? *

1 point

A) Glycation

B) SUMOylation

C) Ubiquitination

D) Palmitoylation

E) Acetylation

Deciphering phenotypic variability and transmission properties of human prion diseases (Plenary 6)

10) The genetic variant that most significantly affects CJD neuropathologic features (over the whole disease spectrum) is: *

1 point

A) The insertion of 48-144 base pairs in the prion protein gene (PRNP) encoding octapeptide repeat insertions

B) The Met/Val polymorphism at PRNP codon 129

C) The E/K substitution at PRNP codon 200

D) The D/N substitution at PRNP codon 178

11) The CJD strains involved in all disease forms/etiologies: sporadic, genetic and acquired are: *

1 point

A) M1 and M2 (Cortical)

B) V2 and V1

C) M1 and V2

D) M1 and M2V (Variant CJD)

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