Clinical Neuropathology QUIZ #10

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Published in Clinical Neuropathology Vol 40 nr.6 (November/December 2021). Based on papers and editorial of Clinical Neuropathology of the same issue.

1. Which of the following inflammation-related antigens is consistently expressed in the sarcolemma in alpha- and gamma-sarcoglycanopathies? *

1 point

a - membrane attack complex (C5b-C9)

b - CD4

c - CD8

d - MHC I

e - p62

2. Which of the following statements regarding muscle biopsy findings in patients with Myasthenia gravis is correct? *

1 point

a - histopathologiical features are characteristic and extensively published

b - a significant percentage of patients have histopathological findings

c - The histology is never normal in biopsies from affected patients

d - angulated fibers have not been documented

e - "ragged red fibers" can never be seen

3. Genetic variations in PLEKHG5 are associated with which of the following? *

1 point

a - lower motor neuron disease

b - autosomal recessive inheritance

c - Charcot Marie Tooth disease

d - abnormal myelination in nerve biopsie

e - all of the above

4. The serum levels of which of the following is not positively correlated with cerebrovascular hemorrhage? *

1 point

a - HDL

b - LDL

c - ferritin

d - neuron specific enolase

e - S100ß

5. Which of the following is an independent risk factor of cognitive impairment in patients with cerebral hemorrhage? *

1 point

a - ferritin levels

b - neuron specific enolase levels

c - S100ß levels

d - smoking

e - all of the above

6. What percentage of pregnancies is approximately complicated by CMV infection? *

1 point

a - less than 0.1%

b - 1-5%

c - 5-10%

d - 10-20%

e - more than 20%

7. Neuropathological findings in congenital CMV infection include which of the following? *

1 point

a - periventricular cysts

b - microcalcifications

c - polymicrogyria

d - neuroglial heterotopia

e - all of the above

8. Which of the following compartments or cells in the CNS may be infected by CMV? *

1 point

a - cortex

b - white matter

c - endothelial cells

d - ependymal cells

e - all of the above

9. Which of the following immunohistochemical markers is typically positive in anaplastic large cell lymphomas? *

1 point

a - CD20

b - CD34

c - CD30

d - CD42b

e - CD117

10. Which of the following statements regarding von Hippel Lindau Syndrome is NOT correct? *

1 point

a - it is associated with renal cell carcinoma

b - it is associated with hemangioblastomas of the cerebellum

c - it is due to an activating mutation of the VHL gene

d - it is inherited in an autosomal dominant fashion

e - neuroendocrine tumors of the pancreas are more frequent in VHL patients

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