1) Which of the followings blood smear finding of RBC in myeloma patient is resulted from hypervicosity?

2) Which of the followings are the International Myeloma Working Group(IMWG) diagnostic criteria for plasma cell myeloma? (more than one answers)
1. Clonal bone marrow plasma cells ≥10% or biopsy-proven bony or extramedullaryplasmacytoma
2. Involved: uninvolved serum free light chain (FLC) ratio ≥100 (involved FLC level must be ≥100 mg/L)
3. >1 focal lesions on magnetic resonance imaging (MRI) studies (at least 5 mm in size)
4.Evidence of end organ damage that can be attributed to the underlying plasma cell proliferative disorder.

3) Whichis the “most” frequent clinical manifestation of plasma cell myeloma in Taiwan ?

4) Which of following parameters shoulded be taken into consideration before starting induction therapy of myeloma? (more than one parameters are correct, choose them all)

1. Patient’s kidney function

2. Resources available

3. Eligibility for autologous stem cell transplant

4. Risk stratification based on bone marrow cell FISH (Fluorescence in situ hybridization) data

5) Which of the following biologic agent is effective and is with well-established evidence in treatment of multiple myeloma?

1. Daratumumab

2. Rituximab

3. Elotuzumab

4. Atezolizumab

5. Belantamab mafodotin