Clinical Neuropathology QUIZ #14

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Published in Clinical Neuropathology Vol 41 nr.4 (July August 2022). Based on papers and editorial of Clinical Neuropathology of the same issue. https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-41-2022/issue/julyaugust-15.html

1. Which of the following genes is implicated in the tumorigenesis of meningioma? *

1 point

A - PTCH

B - TSC1

C - FGFR1

D - NF2

E - CTNNB1

2. Which of the following genetic alterations is known to be associated with more aggressive biological behavior of meningiomas? *

1 point

A - TERT promoter mutation

B - TSC2 mutation

C - NTRK rearrangement

D - ROS1 rearrangement

E - IDH2 mutation

3. Which of the following is a characteristic histological feature of cerebellar liponeurocytoma? *

1 point

A - chondroid matrix

B - Rosenthal fibers

C - melanin pigment

D - lipid accumulation

E - none of the above

4. Which of the following tissues normally contains melanocytes? *

1 point

A - epidermis

B - oral mucosa

C - respiratory mucosa

D - leptomeninges

E - all of the above

5. Which of the following immunohistochemical stains is usually negative in melanocytes? *

1 point

A - Desmin

B - S-100

C - SOX10

D - HMB-45

E - Melan A

6. Which of the following immunohistochemical markers may stain intracytoplasmic inclusions in amyotrophic lateral sclerosis? *

1 point

A - CAM 5.2

B - TDP43

C - Chromogranin

D - EMA

E - Ki67

7. Which of the following is a typical presenting symptom in amyotrophic lateral sclerosis? *

1 point

A - dysarthria

B - tremor

C - memory loss

D - rigidity

E - aphasia

8. Methylation profiling of CNS tumors may provide key information on which of the following diagnostic aspects? *

1 point

A - Tumor type

B - Prognosis

C - MGMT promoter methylation status

D - Clonal relationships between two separate tumors

E - all of the above

9. Which of the following is the target of bevacizumab? *

1 point

A - VEGFR1

B - VEGFR2

C - VEGF-A

D - Tie-1

E - CXCR4

10. Which of the following tumors has been reported to harbor a FGFR1::TACC fusion? *

1 point

A - Pilocytic astrocytoma

B - Pilomyxoid astrocytoma

C - Dysembryoblastic neuroepithelial tumor

D - Extraventricular neurocytoma

E - all of the above

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