16/12/23 - MASLD (3 Cases)
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1) A 60-year-old female with a past medical history of hypertension, type 2 diabetes mellitus, and hyperlipidemia presents for a regular follow-up. The patient has an established diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD). What is the most common cause of mortality in MASLD? *
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2) A 40-year-old presents with increasing fatigue for the last year. Her history is significant for obesity. The patient is currently not taking any medications. The patient denies smoking, alcohol, or any other illicit drug use. Vital signs are temperature 98.6 F (37 C), heart rate 71 bpm, blood pressure 120/76 mm Hg, and respiratory rate 10 breaths/min. Laboratory results are hemoglobin 11 g/dL, WBC 6000/microL, platelet-320,000/microL, AST 160 U/L, ALT 100 U/L, ALP 70 U/L, total bilirubin 0.8 mg/dL, hepatitis panel negative, and iron panel normal. A liver biopsy is performed. What is the most likely finding?
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3) A 60-year-old woman with type 2 diabetes mellitus, hypertension, and dyslipidemia presents for follow-up. She is overweight and does not exercise. Ultrasound of the liver eight months ago showed fatty infiltration. She denies a history of ascites, lower extremity edema, gastrointestinal bleeding, or hepatic encephalopathy. She does not drink alcohol or use recreational drugs. BMI is 31 kg/m2. Laboratory evaluation shows hemoglobin 12 g/dL, WBC count 4.5 X 103 cells/mcL, platelets 132 X 103/mcL, glucose 142 mg/dL, total bilirubin 1.3 mg/dL, AST 72 U/L, ALT 65 U/L, alkaline phosphatase 152 U/L, albumin 3.6 g/dL, and INR 1.3. A liver biopsy is performed that reveals mild macrovesicular steatosis, hepatocyte ballooning, Mallory-Denk bodies, inflammatory cells, and cirrhosis. What is the most appropriate management at this time?
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