Clinical Neuropathology QUIZ #11

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Published in Clinical Neuropathology Vol 41 nr.1 (January/February 2022). Based on papers and editorial of Clinical Neuropathology of the same issue. https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-41-2022/issue/januaryfebruary-10.html

1. Which of the following cells do not typically express TTF-1? *

1 point

a - Follicular cells of the thyroid gland

b - Neurons of hypothalamic hamartoma

c - Mediobasal nuclei of the hypothalamus

d - Cells of a pulmonary adenocarcinoma

e - Cells of a pituicytoma

2. Which of the following is or are possible presenting symptom(s) in patients affected by hypothalamic hamartoma? *

1 point

a - Precocious puberty

b - Gelastic seizures

c - Focal seizures

d - Developmental delay

e - All of the above

3. Which of the following statement regarding subependymal giant cell astrocytoma (SEGA) is not correct? *

1 point

a - The majority of patients with SEGA have tuberous sclerosis

b - SEGA is a clinically malignant tumor

c - SEGA usually involves the lateral ventricle

d - SEGA typically expresses neuronal markers

e - The mTOR signalling pathway is involved in its pathogenesis

4. Which of the following tumors is not associated with tuberous sclerosis? *

1 point

a - SEGA

b - Cardiac rhabdomyoma

c - Angiofibroma

d - Cerebellar hemangioblastoma

e - Retinal hamartoma

5. Which of the following genes is implicated in the pathogenesis of primary meningeal melanocytic neoplasms? *

1 point

a - NF1

b - KRAS

c - GNA11

d - PTEN

e - VHL

6. Which of the following immunohistochemical stains is not likely positive in melanocytoma? *

1 point

a - GFAP

b - Vimentin

c - SOX10

d - Melan A

e - HMB45

Option 6

7. Which of the following is a feature of cerebellar liponeurocytoma? *

1 point

a - Small neurocytic cells

b - Lipid vacuoles

c - Immunoreactivity with synaptophysin

d - Retained ATRX expression

e - All of the above

8. Which immunohistochemical stain is most likely to give a false negative result regarding a mutation in comparison to next-generation sequencing (NGS) in gliomas? *

1 point

a - IDH1

b - ATRX

c - p53

d - H3K27M

e - BRAF

9. Of the follwing genes, which one is most frequently mutated in gliomas and mixed glioneuronal tumors diagnosed within the first year of life? *

1 point

a - BRAF

b - TERT

c - IDH1

d - ATRX

e - IDH2

10. Which of the following tumor types is least common within the first year of life? *

1 point

a - Ependymoma

b - Desmoplasic infantile ganglioglioma

c - Glioblastoma

d - Pilocytic astrocytoma

e - Oligodendroglioma

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