Clinical Neuropathology QUIZ #19

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Published in Clinical Neuropathology Vol 42 nr.3 (May-June 2023). Based on papers and editorial of Clinical Neuropathology of the same issue: https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-42-2023/issue/mayjune-16.html

1. Which of the following is a limiting factor in neuropathological research of autoimmune encephalitides?

1 point

a - no information on temporal evolution of disease may be gained

b - type of inflammatory cells involved cannot be characterized

c - target cells of autoimmune response cannot be defined

d - tissue is rarely available for research

e - all of the above

2. Which of the following is a histological feature of Rasmussen encephalitis?

1 point

a - microglial nodules

b - neuronophagia

c - infiltration by CD3-positive T lymphocytes

d - infiltration by CD8-positive T lymphocytes

e - all of the above

3. Which of the following tumors may harbor a KIAA1549::BRAF fusion?

1 point

a - pilocytic astrocytoma

b - ganglioglioma

c - diffuse leptomeningeal glioneuronal tumor

d - high-grade astrocytoma with piloid features

e - all of the above

4. Which of the following testing modalities for the detection of H3-3A mutations seems to have low sensitivity based on the results of the QuIP round robin trial? *

1 point

a - Sanger sequencing

b - NGS

c - immunohistochemistry with mutation-specific antibodies

d - pyrosequencing

e - all of the above

5 - Clasmatodendrosis may be observed in which of the following conditions?

1 point

a - ischemia

b - traumatic injury

c - hyperglycemia

d - neurodegenerative disease

e - all of the above

6. Which of the following immunohistochemical markers highlights clasmatodendrosis best?

1 point

a - NeuN

b - CK7

c - GFAP

d - synaptophysin

e - EMA

7. Which of the following histological descriptions best fits a diagnosis of inflammatory myofibroblastic tumor?

1 point

a - tumurous proliferation of epitheloid to spindled meningothelial cells

b - dyscohesive sheets of pleomorphic tumor cells with prominent nucleoli

c - a proliferation of histiocytes with grooved or folded nuclei admixed with numerous eosinophils

d - a proliferation of spindle cells arranged in fascicles and/or whorls admixed with an infiltrate of histiocytes, lymphocytes, and plasma cells

e - a proliferation of foamy histiocytes, Touton-type giant cells, small lymphocytes and neutrophils

8. Which of the following immunohistochemical markers is specific for inflammatory myofibroblastic tumor involving the CNS?

1 point

a - GFAP

b - vimentin

c - SMA

d - ALK1

e - none of the above

9. Which of the following lymphomas involving the CNS is most likely to have an unusual clinical presentation and/or radiographic features?

1 point

a - diffuse large B-cell lymphoma

b - intravascular large B-cell lymphoma

c - mantle cell lymphoma

d - immunodeficiency-associated CNS lymphoma

e - all of the above

10. Which of the following clinical indication for biopsy of a non-neoplastic lesion of the CNS is most frequent?

1 point

a - dementia

b - encephalopathy

c - fever

d - hemorrhage

e - headaches

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