Quiz Workshop 3: Pituitary and sellar lesions

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QUIZ QUESTIONS AS SUBMITTED BY THE INVITED SPEAKERS

1) Current 2017 WHO classification of pituitary adenomas is based on: *

1 point

A) Expression of pituitary hormones in the tumour cells

B) Expression of pituitary hormones and pituitary specific transcription factors

C) Tinctorial and ultrastructural features of the tumour cells

D) Expression of pituitary hormones and radiological characteristics of the tumour

2) The term “atypical adenoma” from the previous classification of pituitary tumours has been abandoned. Which of the following designations has replaced the term atypical adenoma in the current 2017 WHO classification of pituitary adenomas? *

1 point

A) Invasive pituitary adenoma

B) Proliferative and invasive pituitary adenoma

C) High-risk pituitary adenoma

D Pituitary carcinoma

3) Which of the statements about neoplasms of the adenohypophysis are correct? *

1 point

A) The field has benefitted from a universally recognised terminology and classification system.

B) Recurrent hotspot mutations are common in PitNETs and offer novel targeted therapies for most patients refractory to standard care.

C) Certain neuropathological features of PitNETs may point to specific underlying mutations.

D) Copy-number variant (CNV) and methylation signatures of PitNETs segregate with established morphological variants of PitNETs.

4) A pituitary incidentaloma is: *

1 point

A) Very rare

B) Always a malignant tumour

C) Quite common

D) Always a gonadotroph tumour

5) Temozolomide therapy for pituitary disease is: *

1 point

A) Standard therapy for aggressive pituitary tumours

B) Not used if O6-methylguanine-DNA methyl transferase (MGMT) has been established in tumour tissue

C) Most effective in clinically non-functioning pituitary adenomas

D) Most effective in prolactinomas

6) The typical clinical phenotype in a patient with a clinically non-secreting pituitary adenoma is: *

1 point

A) Stable over years

B) Changing to e.g. acromegaly

C) Changing to e.g. Cushing’s disease

D) Changing to e.g. TSH-driven hyperthyreose

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