Clinical Neuropathology QUIZ #18

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Published in Clinical Neuropathology Vol 42 nr.2 (March-April 2023). Based on papers and editorial of Clinical Neuropathology of the same issue: https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-42-2023/issue/marchapril-17.html

1. Which of the following tumors have to be considered as histological differential diagnosis for olfactory neuroblastoma?

1 point

a - Sinonasal undifferentiated carcinoma

b - Ewing Sarcoma

c - Metastatic neuroendocrine carcinoma

d - NUT midline carcinoma

e - All of the above

2. Which of the following sarcomas is newly included in the 5th edition of the WHO classification of tumors?

1 point

a - CIC-rearranged sarcoma

b - Leiomyosarcoma

c - Rhabdomyosarcoma

d - Mesenchymal chondrosarcoma

e - Pleomorphic liposarcoma

3. Which of the following statements regarding the expression of PD-1 in olfactory neuroblastoma is correct?

1 point

a - PD-1 is expressed in B-Lymphocytes in the tumor stroma

b - PD-1 expression is higher in tumors of lower Hyams grade

c - PD-1 expression is associated with longer overall survival

d - PD-1 is primarily expressed in the cytoplasm of tumor cells

e - PD-1 expression correlates with Kadish stage

4. Which of the following diseases are caused by triplet repeat expansions? *

1 point

a - Huntington's disease

b - Spinocerebellar ataxia

c - Neuronal intranuclear inclusion disease

d - Friedreich's ataxia

e - All of the above

5. Which of the following sarcomas has the highest incidence in the CNS?

1 point

a - Alveolar soft part sarcoma

b - Desmoplastic small round cell tumor

c - Ewing sarcoma

d - Dedifferentiated liposarcoma

e - Low-grade fibromyxoid sarcoma

6. Which of the following is a sensitive immunohistochemical marker for Ewing sarcoma?

1 point

a - NKX2.2

b - NUT1

c - Desmin

d - BCOR

e - TTF1

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