1-Chronic Kidney Disease 1, 2 (and 3 A/B unless it falls into high/significant risk)
1- Patients less than 60 years who are generally well and whose disease has been stable for > 6 months who are on Hydroxychloroquine alone
2- AI disease affecting their CVS/Respiratory systems such as lung fibrosis
2- Non-autoimmune underlying co- morbidity of `respiratory/cardiovascular system, hypertension or diabetes mellitus
2- Stable chronic Kidney Disease (CKD) stage 3 or above with modest maintenance immunosuppression.
2- Previous adverse infectious complications of immunosuppression – e.g. those with recurrent CMV or chest infections
3- Renal or other organ transplant recipients with CKD
3- Those with End stage kidney disease (ESKD) receiving dialysis.
3- IV induction immunosuppressive medication for autoimmunedisease e.g. receiving cyclophosphamide/Euro lupus regimens or have received cytotoxic / rituximab / other biologic within the last 6 months.
3- Corticosteroid dose of > or = to prednisolone 20mg/day or 35mg/m2/day for more than 4 weeks within the last 6 months.
3- Prednisolone dose of > 5 mg/day, or >0.25mg/kg/day (or equivalent ) for > 4 weeks plus at least one other immunosuppressive medication within the last 6 months.
3- Current nephrotic range proteinuria or who have a history of frequently relapsing nephrotic syndrome.
3- Overall cumulative burden of immunosuppression (IS) is high over a number of years even if their current is in stable maintenance phase e.g. patients who have received repeated courses of cyclophosphamide/biologics/or repeated high dose corticosteroids.
3- Those with well controlled disease activity and no co-morbidity who are on single oral immunosuppressive drugs.
3- Those known to have low IgG levels even if not currently on immunosuppression.
3- B cell depleted despite completing biologic induction treatment more than 6 months previously.
3- Those in disease remission who remain on maintenance low dose prednisolone