Personalized Medicine Debate - Pharmacogenetics; reality or dream?

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In September 2017 the national guideline for colorectal carcinoma was updated to recommend DPD genotyping before treatment with fluoropyrimidines. This is an example of personalized medicine as a result of the developments in the field of Pharmacogenetics.

Effective implementation of pharmacogenetic guidelines, clinical utility of genotyping vs phenotyping at the enzyme level, the cost-effectiveness of such approaches, and the innovative application of a pre-emptive pharmacogenomics panel are subjects of study within the APH-Personalized Medicine program.

With this debate, we hope to evaluate and stimulate responsible implementation of pharmacogenomics, as well as other personalized medicine approaches, in light of our proposed value-based healthcare framework. We hope to discuss the relevance of (transparency about) the different values at stake when evaluating personalised medicine application.(see white paper)

CONFIRMED SPEAKERS:
Dr. Pierre Bet,  Clinical Pharmacologist (Amsterdam UMC, location VUmc)
Prof. Martina Cornel, Community Genetics & Public Health Genomics (Amsterdam UMC, location VUmc)
Prof. Henk van Weert, Professor of General Practice- Diagnostic decision support in general practice (Amsterdam UMC, location AMC)
Assistant Professor Anke Hövels, Consultant HTA and health economics (UMCU)


Propositions:
- Clinical utility of available tests should be the main criterion for implementation
- Clinicians have a responsibility to weigh the allocative value of the available interventions for their patients
- Patients should have the right to have access to their pharmacogenetic data, if whole exome sequencing is performed
- Avoiding harm (side-effects) is a more appropriate aim for pharmacogenomics than beneficence (predicting desired effects)


Program:
14:45 – 15:00 Opening with coffee and tea
15:00 - 15:20: General Introduction – Pierre Bet
15:20 – 15:30: Martine Cornel - DPD testing before treatment
15.30 - 16.00: Response from debaters (Henk van Weert, Anke Hövels, Martina Cornel, NPCF)
16:00 - 16:40: Propositions
16:40 - 16:45: Closure
16:45 - 17:30: Drinks