Clinical Neuropathology QUIZ #8

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Published in Clinical Neuropathology Vol 40 nr.4 (July/August 2021). Based on papers and editorial of Clinical Neuropathology of the same issue (for your reference: https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-40-2021/issue/julyaugust-14.html)

1. CCND2 amplification is a prognostic factor in which of the following gliomas? *

1 point

A - Glioblastoma, IDH wildtype

B - Oligoendroglioma, IDH mutant and 1p/19q codeleted

C - Diffuse midline glioma, H3 K27-altered

D - Astrocytoma, IDH mutant

E - all of the above

2. Which of the following molecular alterations are of prognostic significance in diffuse astrocytic gliomas? *

1 point

A - EGFR amplification

B - TERT promoter mutation

C - Gain of chromosome 7 with loss of chromosome 10

D - Tumor mutational burden

E - all of the above

3. Which of the following immunohistochemical markers distinguishes infantile hemangioma from capillary hemangioma? *

1 point

A- CD31

B - GLUT-1

C - CD34

D - ERG

E - MYC

4. Which of the following statements regarding infantile hemangioma is NOT correct? *

1 point

A - Intracranial infantile hemangioma is rare.

B - Infantile hemangioma is associated with a risk of malignant progression.

C - Cases reported in the literature affected newborns/infants

D - Intracranial infantile hemangioma may be associated with edema

E - Infantile hemangioma may cause significant morbidity

5. Which of the following immunohistochemical markers is NOT expressed in epitheloid angiosarcoma? *

1 point

A - Cytokeratin

B - Vimentin

C - CD31

D - ERG

E - HMB45

6. Which of the following entities should be considered in the differential diagnosis of a dural based tumor with epithelioid morphology? *

1 point

A - Rhabdoid meningioma

B - Epithelioid glioblastoma

C - Metastatic carcinoma

D - Epithelioid hemangioendothelioma

E - all of the above

7. Which of the following statements regarding Rosai-Dorfman Disease is NOT correct? *

1 point

A - it is composed of Langerhans histiocytes

B - it may involve multiple organs

C - histological findings include an accumulation of histiocytes

D - emperipolesis is a salient diagnostic feature

E - fever may occur in some patients

8. Which of the following immunohistochemical markers is NOT expected to be positive in infiltrates of Rosai Dorfman disease? *

1 point

A - CD68

B - S100

C - CD1a

D - CD3

E - CD20

9. Which of the following neoplasms does not occur with increased frequency in patients affected by neurofibromatosis type 1? *

1 point

A - Pilocytic astrocytoma

B - Glioblastoma

C - Pheochromocytoma

D - Papillary carcinoma of the thyroid gland

E - Gastrointestinal stromal tumor

10. Which molecular alteration is commonly found in NF1-associated gliomas? *

1 point

A - EGFR amplification

B - Histone H3 mutation

C - Alteration of the RAS/MAPK pathway

D - C19MC alteration

E - mutation of the beta catenin gene

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