The goal of this symposium is to bring together researchers and practitioners at the intersection of AI and Science, to discuss opportunities to use AI to accelerate scientific discovery, and to explore the potential of scientific knowledge to guide AI development. The symposium will provide a platform to nurture the research community, to fertilize interdisciplinary ideas, and shape the vision of future developments in the rapidly growing field of AI + Science. The symposium will include a combination of invited talks, posters, panel discussions, social and networking events.