Clinical Neuropathology QUIZ #2

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Published in Clinical Neuropathology vol 39, issue 5 (September/October 2020). Based on papers and editorial of Clinical Neuropathology of the previous issue (issue 4, July/August 2020) which you can access here: https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-39-2020/issue/julyaugust-13.html

1. All of the following are typical histologic features of measles inclusion body encephalitis EXCEPT *

1 point

a - A prominent lymphocytic infiltrate

b - Multinucleated cells

c - Microglial nodules

d - Eosinophilic intranuclear inclusions

e - Gliosis

2. Which of the following statements regarding measles encephalitis is TRUE?

1 point

a - The incidence in developed countries has been steadily decreasing

b - It is caused by a double-stranded RNA-virus

c - Measles encephalitis may develop weeks to years after the primary infection

d - Subacute sclerosing panencephalitis (SSPE) is typically associated with a poor immunological response

e - Measles inclusion body encephalitis is more frequent in immunocompetent than immunocompromised individuals

Clear selection

3. Which of the following statements is TRUE concerning Pick's Disease? *

1 point

a - the clinical presentation includes behavioral anomalies and aphasia

b - Gallyas does not stain Pick bodies because it is sensitive to the 4R tau-isoform

c - Familial cases of Pick's Disease due to mutations in exons 9-13 in the tau-gene have been reported

d - in an experimental setting, brain homogenates from human tauopathies can induce tau-filaments when injected into mouse brains

e - All of the above

4. Which of the following statements regarding neurofibromatosis type 2 is true? *

1 point

a - most of the cases are familial

b - It is caused by a mutation of the NF2 tumor suppressor gene located on chromosome 9

c - Neurofibromatosis type 2 is commonly associated with perineuriomas

d - NF2 is inherited in an autosomal-dominant fashion

e - none of the above

5. Which of the following statements regarding perineuriomas is correct? *

1 point

a - They may be subdivided into soft tissue neuromas, intraneural perineuriomas and sclerosing perineuriomas

b - Intraneural perineuriomas are exclusively due to TRAF7 gene mutations

c - By immunohistochemistry, these tumors are typically negative for INI1.

d - Perineuriomas often have alterations in both TRAF7 and NF2 genes.

e - all of the above.

6. A mutation in which of the following genes is reported to be associated with a progression from anaplastic ependymoma to ependymosarcoma in the case report by Pujadas et al? *

1 point

a - RB1

b - TSC1

c - TSC2

d - TP53

e - BRAF

7. Which of the following categories of anaplastic gliomas is not defined by the WHO 2016 classification of Tumours of the Nervous System? *

1 point

a - Anaplastic astrocytoma, IDH mutant

b - Anaplastic oligodendroglioma, IDH mutant and 1p/19q co-deleted

c - Anaplastic astrocytoma, IDH wildtype

d - Anaplastic oligoastrocytoma, NOS

e - Anaplastic oligodendroglioma, IDH wildtype and 1p/19q intact

8. Which of the following are known prognostic factors in anaplastic gliomas? *

1 point

a - patient age

b - tumor location

c - IDH mutation status

d - extent of resection

e - all of the above

9. Which of the following is a common histological/immunohistochemical feature of chondroma? *

1 point

a - low proliferation index

b - presence of fibrous cartilage

c - spindle cell components

d - admixed connective tissue

e - positivity for EMA

10. Chondromas of the meninges … *

1 point

a - perhaps develop from multipotential mesenchymal cells of the meninges

b - are rare neoplasms

c - may mimic meningioma on imaging studies

d - thus far have not been associated with IDH1/2 or HMGA2 mutations

e - all of the above

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