Quiz Symposium 11: Intratumoral heterogeneity

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QUIZ QUESTIONS AS SUBMITTED BY THE INVITED SPEAKERS

1) How does the average DNA methylation level of IDH wildtype glioblastoma relate to IDH mutant lower grade glioma? *

1 point

A) There is no difference.

B) IDH wildtype tumors show on average higher DNA methylation levels as compared with IDH mutant lower grade glioma

C) IDH mutant glioma shows higher DNA methylation levels as IDH wildtype glioblastoma

2) The final equilibrium of tumor phenotypic states is driven by: *

1 point

A) Genetic and epigenetic aberrations of tumor cells

B) Tumor microenvironmental cues

C) Treatment pressure

D) All of the above

3) CD133+ GBM cells are: *

1 point

A) A cellular GBM phenotypic state enriched in hypoxic microenvironment

B) GBM cancer stem cells at the apex of hierarchical organization of GBM

C) The only self-renewing GBM subpopulation

D) Neural stem cells in the subventricular zone

4) Which of the following statements are correct?

1 point

A) Glioma cells that invade the brain do not divide (the Go or Grow hypothesis)

B) Glioma cells that invade the brain can divide.

C) Secondary brain tumors show similar invasion patterns in the brain as primary brain tumors

D) IDH1 mutated glioblastomas show limited invasion capacities in the brain parenchyma I

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