Quiz Symposium 2: Genetics of Neurodegeneration

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QUIZ QUESTIONS AS SUBMITTED BY THE INVITED SPEAKERS

1) If Lewy bodies are seen in the cingulate cortex of a PD patient at post-mortem, what is the minimal alfa-synuclein Braak stage assigned to the case? *

1 point

A) III

B) IV

C) V

D) VI

2) In which of these genetic forms of PD are Lewy bodies usually absent? *

1 point

A) Parkin

B) PINK1

C) LRRK2

D) DJ-1

3) The SOD1 transgenic mouse model is a useful model for: *

1 point

A) TDP-43 proteinopathy.

B) Sporadic ALS/MND.

C) SOD1-related familial ALS/MND.

D) Translation of small molecule drugs into successful human clinical trials.

4) In relation to ALS/MND caused by mutations in C9ORF72: *

1 point

A) The disease is a pure TDP43-proteinopathy.

B) TDP-43 negative protein aggregates are found in extra-motor system areas.

C) Motor neuron injury is caused by a loss of function mechanism.

D) Full disease penetrance is observed in the presence of a pathogenic intronic hexanucleotide expansion.

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