Tumor lysis syndrome (1 to 3 of 5) 02/02/24

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1) A 50-year-old man with newly diagnosed Burkitt's lymphoma is starting chemotherapy. Three days after initiating treatment, he develops nausea, vomiting, weakness, and oliguria. Laboratory studies show hyperkalemia, hyperphosphatemia, hyperuricemia, and hypocalcemia. What is the most likely diagnosis?

1 point

a. Acute kidney injury

b. Tumor lysis syndrome

c. Chemotherapy-induced nausea and vomiting

d. Metabolic acidosis

e. Septic shock

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2) A 49-year-old presents with a loss of consciousness. Her family members say she had 2 to 3 episodes of non-bilious vomiting before losing consciousness. She started on chemotherapy for Burkitt's lymphoma 2 days ago. On physical examination, she is not oriented to time, place, or person. Laboratory testing reveals a potassium level of 6.4 mEq/L, a phosphorus level of 6.8 mg/dL, a calcium level of 6.9 mg/dL, and a uric acid level of 9.0 mg/dL. An ECG shows a normal sinus rhythm. What is the next step in management?

1 point

a. Intravenous fluid hydration

b. Allopurinol

c. Calcium gluconate

d. Febuxostat

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3) A 45-year-old woman presents with nausea, vomiting, muscular weakness, and generalized pruritis. Her history is significant for Burkitt’s lymphoma currently under treatment. Vital signs are normal. Physical examination shows bilateral rhonchi and pedal edema. What is the most common complication associated with tumor lysis syndrome?

1 point

a. Pancreatitis

b. Acute kidney injury

c. Megacolon

d. Hepatic dysfunction

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