How Do Muscles Respond to Exercise After Temporary Physical Inactivity?
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After completing this brief questionnaire, more detailed information will be given to you before you decide whether or not to take part in the research, and you will have the opportunity to speak with and ask questions of a study coordinator. You can stop this interview at any time.
Please note that by completing this questionnaire, you consent to us collecting your answers to the questions, including your contact information.
Are you willing to continue? * *
Are you between 50 to 65 years old? (You must be between 50 to 65 years old to participate) *
How old are you? (please put your age in years) *
When is your date of birth? (mm/dd/yyyy) *
First name *
Last name *
Cell phone number *
Zip code *
Height (in feet) *
Height (in inches) *
Weight (pounds) *
Gender *
Are you able to physically attend the research site for 9 study visits over approximately a 3 to 4 week period? Note: Exercise sessions that are 30-60 mins each and all other visits are 2-3 hrs.

(Please note some of the visits can take place at our UTMB League City campus if that is more convenient)
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This study requires that those enrolled participants in 1 week of single leg disuse and the use of a leg sling and crutches. 
Are you willing to wear a leg sling for 7 days as required in the study?
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Are you willing to undergo muscle biopsies in the thigh?  

The muscle biopsy procedure involves the taking of a small piece of muscle tissue from the outer side of your upper leg, about 4-6 inches above the knee. The skin is cleaned and injected with local anesthetic (numbing medicine) to minimize any pain. A small incision will be made in the skin, through which a needle (approx. 8mm circumference) is advanced into the muscle. A small piece of the muscle is then removed with the needle, the skin is closed with a special medical glue or suture, and a light dressing is applied. Muscle biopsies will be performed by fully trained, qualified medical personnel. 
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Are you able to walk without assistance?
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Do you do work that requires any of the following?

- standing uninterrupted for more than an hour
- lifting or carrying
- manual labor
- any other activity that cannot be performed while wearing a knee brace
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Do you have low testosterone? (Males only) *
Do you have any of the following medical conditions?

- uncontrolled blood pressure 
- diabetes
- blood clots/stroke/pulmonary embolism
- recently treated cancer other than basal cell carcinoma (within 3 years)
- heart, lung, or vascular disease
- impaired kidney function
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Have you taken testosterone, steroids, growth hormones, or immunosuppressants in the last 12 months? *
Are you currently on a weight loss diet? *
Are you engaged in alcohol or substance abuse?
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Are you currently participating in another clinical trial?
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Please select a date for the study team to reach out to you with a phone call *
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Please select a time for the study team to reach out to you with a phone call
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Are you committed to answering your phone when the research team reaches out to you at the appointed date and time? *
A copy of your responses will be emailed to the address you provided.
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