Webinar with Dr Budsberg (BI Cpd Series)

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1) Which is the most common initiating cause of osteoarthritis in the dog?

1 point

a) Mechanical stressors – either developmental or structural

b) Direct joint trauma

c) Inflammation – infectious or immune mediated

d) Panosteitis

e) None of the above

Clear selection

2) Osteoarthritis affects which of these components of a diarthrodial joint?

1 point

a) Articular cartilage and subchondral bone

b) Ligaments and joint capsule

c) Synovial membrane

d) All of the above

e) None of the above

Clear selection

3) Which of the following statements best describes the course of OA in the dog?

1 point

a) With appropriate treatment, OA can be reversed

b) OA is an insidious inflammatory disease and once it begins, it will slowly progress

c) OA is generally a rapidly progressive disease in dogs

d) Diarthrodial joints are rarely involved

e) None of the above

Clear selection

4) Which of the following statements about abnormal mechanical stressors in the dog’s joint is false?

1 point

a) They result in adaptive changes to both the articular surface and subchondral bone

b) They result in the release of inflammatory cytokines/mediators, such as PGE2

c) They result in the release of catabolic mediators (matrix degenerating enzymes) that damage cartilage

d) They facilitate joint adaptive changes that mitigate inflammation and pain, allowing the dog to ambulate pain-free

e) None of the above

Clear selection

5) With respect to inflammation and OA, which of the following statements is false?

1 point

a) OA is a non-inflammatory condition

b) Low-grade chronic inflammation perpetuates a vicious cycle of OA progression

c) Inflammation leads to joint swelling, pain, and lameness

d) Inflammation mediators come from both the chrondrocytes and synovium

e) None of the above

Clear selection

6) OA pain is facilitated by which of the following factors?

1 point

a) Activation of mechanical nociceptor as a result of abnormal joint movement

b) Inflammatory mediators and cytokines released as part of the chronic low-grade inflammation that typifies progressive OA in the dog as well as from nervous tissue (neurogenic inflammation)

c) Peripheral and central sensitization

d) All of the above

e) None of the above

Clear selection

7) With regards to prostaglandin E2 (PGE2) generated by cyclooxygenase-2 (COX-2), which of the following statements is false?

1 point

a) PGE2 upregulates and perpetuates the vicious cycle of joint inflammation

b) PGE2 results in apoptosis or loss of chondrocytes leading to cartilage degradation

c) PGE2 can be effectively mitigated through the use of NSAIDs

d) PGE2 is a minor inflammatory mediator in progressive OA

e) None of the above

Clear selection

8) With regards to initiation and continuation of OA treatment, which of the following statements is correct?

1 point

a) OA treatment should only begin if confirmed through radiographic evidence of joint pathology

b) Radiography correlates very well with clinical symptoms

c) Treatment should be based primarily on the dog’s clinical signs, physical examination, and response to treatment

d) Treatment should be based on and progression monitored via the testing of OA biomarkers

e) None of the above

Clear selection

9. What is the characteristic of the preclinical phase of DMVD?

1 point

a) The added weight bearing associated with obesity can add to increased joint mechanical stressors

b) Fat tissue has been demonstrated to be an endocrine organ that release adipocytokines that are pro-inflammatory

c) Obesity has not been identified as a significant contributor to progressive OA

d) Management of obesity is a sound therapeutic strategy

e) None of the above

Clear selection

10) With regards to the general principles of OA treatment, which of the following statements is correct?

1 point

a) NSAIDs is a foundational therapy in the management of OA due to their anti-inflammatory and analgesic properties

b) Management of obesity is a critical therapeutic focus

c) Chronic OA is best managed through a multi-modal approach

d) All of the above

e) None of the above

Clear selection

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