Clinical Neuropathology QUIZ #7

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Published in Clinical Neuropathology Vol 40 nr.3 (May/June 2021). Based on papers and editorial of Clinical Neuropathology of the same issue (for your reference: https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-40-2021/issue/mayjune-14.html)

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1. Which of the following statements regarding cerebral venous thrombosis is correct (chose the single best answer)? *

1 point

A - may be associated with an infectious process of the CNS

B - is frequently located in the superior sagittal sinus

C - may be due to hyper coagulability

D - may be caused by inflammation of the vessel wall

E - all of the above

2. Which conclusion can be drawn from the autopsy study on cerebral venous thrombosis? *

1 point

A - cerebral venous thrombosis is mostly caused by meningitis

B - Staphylococcus is often the causative microorganism

C - depending on the pathogenesis (infectious or aseptic), different treatment approaches may be warranted

D - cerebral venous thrombosis is not associated with intracranial hemorrhage

E - Antibiotic treatment must be administered to all patients affected

3. What is a collision tumor? *

1 point

A - a carcinoma which displays sarcomatous differentiation

B - a meningioma with chordoid morphology

C - a Glioblastoma with epitheloid morphology

D - the co-localization of two separate neoplasms

E - none of the above

4. Which of the following antibodies may be expected to stain both chordomas and meningiomas? *

1 point

A - EMA

B - AE1/AE3

C - Brachyury

D - Progesterone Receptor

E - Synaptophysin

5. Which of the following phenotypes has not been linked to KIF5A gene mutations? *

1 point

A - Amyotrophic Lateral Sclerosis

B - Charcot-Marie-Tooth peripheral neuropathy type 2

C - Hereditary spastic paraplegia type 10

D - Hereditary spastic paraplegia with peripheral neuropathy

E - Spinocerebellar ataxia type 1

6. Which of the following statements regarding tumor stem cells is incorrect? *

1 point

A - few stem cells may give rise to an entire tumor mass

B - they may be progenitors of morphologically diverse tumor cells

C - the concept of tumor stem cells was originally described in hematological malignancies

D - they may be relatively resistant to radiation

E - they represent the majority of cells in most tumor types

7. Which aspect of immunohistochemical staining with CD133 represents a challenge? *

1 point

A - finding reliable positive and negative controls

B - heterogenous staining of tumor sections

C - different staining results depending on the antibody clone used

D - different staining patterns

E - all of the above

8. Corticobasal degeneration is associated with abnormal aggregation of which of the following? *

1 point

A - alpha-synuclein

B - TDP-43

C - hyperphosphorylated tau

D - PrPSc

E - FUS

9. Which of the following symptoms is not commonly associated with corticobasal syndrome *

1 point

A - akinesia

B - myoclonus

C - sensory loss

D - dysphagia

E - apraxia

10. Which of the following histologic features has not been specifically linked to IDH-wildtype glioblastomas with FGF3:TACC3 fusion? *

1 point

A- monomorphic tumor cells

B - a „chicken wire“-capillary network

C - multinuclear giant tumor cells

D - perivascular pseudo rosettes

E - microcalcifications

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