LIPID METABOLISM

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LIPID METABOLISM

There are 40 MCQs on LIPID METABOLISM. Prepared By: Dr Amit Maheshwari

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22. Acetyl CoA acts as a substrate for the all the enzymes except

1 point

A HMG CoA Reductase

B Malic enzyme

C Malonyl CoA Synthetase

D Fatty acid Synthesis

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38. Familial hypercholesterolemia is a genetic disorder of lipid metabolism. The defect lies in

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A. Transport of Cholesterol from extra hepatic tissue to liver

B. Impairment of cholesterol degradative pathway

C. Impairment of uptake of cholesterol by tissue

D. Impairment of HDL metabolism due to deficiency of Apo-A

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21. Acetyl CoA carboxylase is activated by

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A malonyl CoA

B Citrate

C Palmitoyl CoA

D Acetoactate

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34. What is the outcome of accumulation of Acetyl Co-A in the mitochondria of liver

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A. It is used as energy sources

B. It has broken down into free fatty acids

C. It get converted to Oxaloacetate

D. It form ketone bodies

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30.Name the most active organ in human body which have ability to synthesize TAG? *

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A. Spleen

B. Kidney

C. Adipose Tissues

D. Liver and intestines

9. LDL receptor recognises the following apoprotein

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a. apo A-1

b. apoc -II

c. apo B-100

d. apo B-48

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19. Which of the following is not a part of the fatty acid synthase complex

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A ketoacyl reductase

B Enoyl reductase

C Acetyl CoA carboxylase

D Ketoacyl Synthase

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8. the following enzyme is not the part of the Fattyacid synthase complex.

1 point

a. ketoacyl synthase

b. acetyl transacylase

c. acetyl coA carboxylase

d. malonyl transacylase

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10. which one of the following apoprotein activates lipoprotein lipase ?

1 point

a. apo A-1

b. apo B-100

c. apo c-II

d. apo E

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31 .Which of the following pathway is not used for TAG synthesis? *

1 point

A. Glycerol-3-Phosphate pathway

B. Glyoxylate pathway

C. Monoacyl glycerol pathway

D. Kennedy pathway

1. A defective 'ABC protein' cuases

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a. abetalipoproteinemia

b. hypobetalipoproteinemia

c. type IIB hyperlipidemia

d. Tangier's disease

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15.which of the following lipoprotein consists of highest amount of TG among all lipoproteins.

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a. HDL

b. LDL

c. VLDL

d. Chylomicron

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4. wolman's disease is due to

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a. deficiency of cholesterol acyl hydrolase

b. deficiency of lysosomal acid lipase

c. LCAT

d. ACAT

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14. a patient was diagnosed with isolated increase in LDL. he had family history of his father and brother with same scenario increased LDL and cholesterol. The likely diagnosis is-

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a. Familial type -III hyperlipoproteinemia

b. abetalipoproteinemia

c. familial lipoprotein lipase deficiency type1

d. Familial hypercholesterolemia type IIa

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25. Toxicity of Ethanol is due to:

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a. Increased NADH/NAD+ ratio

b. Decreased lactate/Pyruvate ratio

c. Inhibition of Gluconeogenesis

d. Stimulation of fatty acid oxidation

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40. Refsum's disease results from a defect in the following pathway EXCEPT

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A. Alpha oxidation of fatty acids

B. Beta oxidation of fatty acids

C. Gamma oxidation of fatty acids

D. Omega oxidation of fatty acids

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36. The following require cholesterol EXCEPT

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A. Bile acid synthesis

B. Steroid hormone synthesis

C. Membrane fluidity

D. Thyroid hormone synthesis

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32. Which of the following hormone is not used in hydrolysis of TAG into fatty acids in Adipose tissue?

1 point

A. Epinephrine

B. Norepinephrine

C. Glucagon

D. Insulin

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6. absence of peroxisomes in the tissues results in

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a. Refsum's disease

b. zellweger syndrome

c. SIDS

d. methylmalonic acidemia

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26. Best explained pathogenesis of fatty liver in alcoholic liver disease:

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a. Increased hydrolysis of fat from adipocytes

b. Decreased synthesis of fatty acids

c. Decreased [NADH]/[NAD+] ratio

d. Impaired beta oxidation of fatty acids

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12. ATP yield in stearic acid oxidation(beta oxidation) -

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a. 146

b. 120

c.122

d. 106

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29. Number of ATP formed by oxidation of one molecule of palmitic acid (16 c):

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A 146

B 106

C 135

D 34

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7. A defect in the enzyme hexosaminisase causes

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a. gaucher's disease

b. farber's disase

c. Tay-sach's disease

d.krabbe's disease

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5. one of the following lipoprotein act as a repository of transferrable apoproteins

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a. IDL

b. VLDL

c.HDL

d. LDL

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11. ketone body formation without glycosuria seen in

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a.Diabetes mellitus

b.diabetes insipidus

c. prolonged starvation

d. obesity

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16. Which of the following organ utilizes glucose, fatty acid, and ketone bodies as fuel ?

1 point

A Heart

B Liver

C RBC

D Brain

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37. Which of the following lipid act as lung surfactant?

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A. Phosphotidylcholine

B. Ceramide

C. Phosphotidylethanolamine

D. Phosphotidylinositol

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18. The immediate precursor in the formation of acetoacetate from acetyl CoA in the liver is

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A mevalonate

B HMG-CoA

C Acetoacetyl CoA

D 3 hydroxylbutryl CoA

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33. Mark INCORRECT statement about the bile salt

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A. These are detergent substances

B. Stored in Gall bladder

C. It is hydrophobic in nature

D. It is made up of cholic acid

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17. Ketone bodies can be utilized by all, except:

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A RBC

B Brain

C Skeletal Muscle

D Renal Cortex

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28.One of the following is obtained in the beta oxidation of odd chain fatty acids:

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A Acetyl CoA + Acetyl CoA

B Acetyl CoA + Propionyl CoA

C Propionyl CoA + Propionyl CoA

D Acetyl CoA

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3. the enzyme associated with reverse cholesterol transport is

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a. LCAT

b.ACAT

c. Cholesterol ester hydrolase

d.HMG CoA synthase

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13. Hormone sensitive lipase is not activated by

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a. insulin

b. Glucagon

c. catecholamines

d. T4

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2. The rate limiting enzyme of cholesterol biosynthesis is

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a. squalene epoxidase

b. mevalonate kinase

c.HMG CoA synthase

d. HMG CoA reductase

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24. All are derived from cholesterol Except

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A Vitamin D

B Bile Salt

C Bile Pigment

D Steroid

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39. Dipalmitoyl Lecithin act as

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A. Platelet activating factor

B. Second messenger for hormone

C. Lung surfactant

D. Anti-ketogenic compound

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20. Mitochondria is involved in A/E

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A. Fatty acid synthesis

B DNA synthesis

C Fatty acid oxidation

D Protein synthesis

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27. In well fed state, activity of CAT1 in outer mitochondrial membrane is inhibited by ;

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A. Glucose

B Acetyl CoA

C Malonyl CoA

D Pyurvate

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35. Name the energy source of brain during starvation?

1 point

A. Fat

B. Ketone bodies

C. Protein

D. Lipids

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23. Common enzyme in cholesterol and ketone body metabolism

1 point

A HMG CoA Reductase

B HMG CoA Lyase

C HMG CoA synthase

D Thiolase

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