Skin signs of Poisoning (3 MCQs) 19/04/24

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1) A 64-year-old female with dermatitis herpetiformis presented with confusion, lightheadedness, weakness, and mild headache, as well as a greyish discoloration of the skin. She recently started dapsone, and her CBC was within normal limits. Despite treatment with 100% oxygen, the discoloration remained. What is the most likely diagnosis? *

1 point

a. Drug-induced dyspigmentation

b. Methemoglobinemia

c. Raynaud disease

d. Metabolic acidosis

e. Congestive heart failure

2) A 6-month-old infant is brought to the emergency room by his parents with complaints of cyanosis, lethargy, and difficulty breathing. The parents report that the infant had been given a teething gel containing benzocaine a few hours prior to the onset of symptoms. Physical examination reveals cyanosis of the lips and mucous membranes. Pulse oximetry readings show oxygen saturation levels persistently around 85%. Which of the following mechanisms is most likely responsible for the symptoms observed in this infant?
*

1 point

a. Inhibition of cytochrome oxidase

b. Oxidative damage to erythrocytes

c. Binding of oxygen to hemoglobin

d. Methemoglobin formation

3) A 45-year-old woman presents to the clinic with complaints of headache, dizziness, and generalized weakness. She reports recent exposure to a household cleaner containing nitrites while cleaning a poorly ventilated bathroom. Physical examination reveals cyanosis of the lips and nail beds. Laboratory investigations show elevated levels of methemoglobin in the blood. Which of the following is the most likely cause of her symptoms? *

1 point

a. Carbon monoxide poisoning

b. Sulphemoglobinemia

c. Methemoglobinemia

d. Lead poisoning

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