CLICC day 5 - Sports cardiology and genetics

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Please complete the following questions to receive your attendance certificate.

Passing is 5 of 6 correct questions.

You may review the correct answers after submission, and can retake the quiz as many times as needed.

Email *

Full name (for certificate) *

Which of the following cannot be considered a normal adaptation in athlete’s heart? *

1 point

T-wave inversion in V1 and V2 with right ventricular dilatation

Left ventricular hypertrophy of 13mm in a black athlete with T-wave inversion in V1-V4

An elite cyclist with a heart rate of 39 beats per minute, LV cavity dimension of 62 mm, and resting LV ejection fraction of 52%

A resting heart rate of 47 beats per minute and corrected QT interval of 440 msec in an asymptomatic male athlete

A black athlete with an LV wall thickness of 12 mm and T-wave inversion in V5, V6, I and aVL

Based on the 2020 ESC Sports Cardiology and exercise guidelines in patients with cardiovascular disease the following statement is TRUE:

1 point

High intensity exercise may be considered in individuals who are genotype positive but phenotype negative for ARVC

Participation in high intensity exercise may be considered in individuals with HCM who are considered at low risk of arrhythmias

Patients with Long-QT syndrome (QTc: 490msec) who are asymptomatic on optimal beta-blocker treatment can participate in competitive sports

The risk of arrhythmias in HCM is similar irrespective of age, sex, sporting discipline

The following are recognised causes of inferior / lateral T-wave inversion in athletes (check all that apply): *

1 point

HCM

Covid myocarditis

Aberrant papillary muscle attachment

Ethnic variant

Hypertension

Required

Nancy is a 38 year old diagnosed with HCM who was sent for genetic testing.

The report detailed two variants; one classified as Likely Pathogenic and the other as a variant of uncertain significance (VUS).

Which, if either, of these variants can be used clinically to screen family members for their risk of developing disease, and why?

1 point

Neither, as only variants classified as Pathogenic are clinical actionable

The Likely Pathogenic variant, as variants that are either Pathogenic or Likely Pathogenic are clinically actionable

Both, as only variants that are Benign or Likely Benign cannot be used clinically

Neither, as genetic variants can never be used to screen family members

Both, as there is a chance that the VUS is Pathogenic

Please select the INCORRECT statement from the list below: The National Genomic Test Directory: *

1 point

Is updated annually to incorporate developments in clinical practice and scientific knowledge

Contains all of the DNA-based tests available to request for NHS patients in England

Is only available if you work in a clinical genetics unit

Contains a range of tests from single gene tests through to whole genome sequencin

Describes which patients are likely to benefit from testing across all clinical specialties

One may offer predictive testing to family members of a patient with an inherited cardiac condition who was found to have a genetic variant in one of the ICC genes, if the variant has been classified as: *

1 point

A variant of uncertain significance (VUS)

A likely benign variant

A likely pathogenic or pathogenic variant

A benign variant

Overall , how would you rate the session? *

Excellent

Good

Average

Poor

Very poor

Please rate the speakers using a scale of 1-5 (where 1 = poor and 5 = excellent): *

Co chair Abbas Zaidi

Co chair Ellie Quinn

Aneil Malhotra

Nabeel Sheikh

Michael Papadakis

Graham Stuart

Zaheer Yousef

Matthew Edwards

Debbie Morris-Rosendhal

Ellen Thomas

Brian Halliday

Stephanie Oates

Samantha Mason

How did you find the session length? *

Much too long

Too long

About right

Too short

Much too short

What went well?

What could we do better?

Do you have any future topics you would like for us to cover?

What motivated you to attend this course?

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