AFRAN Nephro-Pathology Monthly Case (January 2022)
Case developed by:
Mohammed Abdel Gawad (Egypt), Wessam Ismail (Egypt), Rim Goucha (Tunisia)

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Case History: A 24-year-old man presented with mild edema and hypertension developed several months ago. There is history of frequent attacks of hematuria that resolved spontaneously. Now the patient is presented by sub-nephrotic proteinuria (2.1 g/24h), serum creatinine: 3.1 mg/dL, BUN: 75 mg/dL. Urine analysis showed: proteinuria: ++, 25-30 red blood cells/hpf.  All markers of autoimmunity and infections were negative.  See the images of the renal biopsy and differential diagnosis below then choose the most accurate answer.
Q1- What is the seen pathology in this LM PAS stain section? (Reference of the image: AJKD VOLUME 66, ISSUE 5, E33-E34, NOVEMBER 01, 2015) *
1 point
Captionless Image
Q2- What is the site of the seen deposits in the next EM? (Reference of the image: AJKD VOLUME 66, ISSUE 5, E33-E34, NOVEMBER 01, 2015) *
1 point
Captionless Image
Q3- Check the next 3 images showing the IF of the above case then choose what is your diagnosis (note: other IF markers are negative)? *
1 point
IF:  Direct immunofluorescence for IgG (Reference of the image: www.kidneypathology. com Case 153)
IF: Direct immunofluorescence for IgA  (Reference of the image: www.kidneypathology. com Case 153)
IF:  Direct immunofluorescence for C3 (Reference of the image: www.kidneypathology. com Case 153)
Q4- Which of the following drugs is recently approved to use in the previous case to delay CKD progression? *
1 point
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