7, Although it was first isolated in 1820 from the bark of a cinchona tree, legend has it that it had been used to treat malaria since at least 1632 and was introduced to Spain as early as 1636 by Jesuit missionaries. According to their legends, the first discoverer was a feverish Andean man who was lost in the jungle. Suffering from malaria, he drank from a pool of water at the base of a cinchona tree. Although bitter to the taste, his fever lifted and he survived to pass on what he had learned. Which famous discovery?