ENIGMA-CHARGE (ICV, Hipp Vol, Subcortical) GWAS summary statistics download agreement
Please fill out this form to access GWAS summary statistics from one or more of the following 3 publications. You may request access to the results from more than one paper, as long as the research proposal applies to all publications requested. If access is granted you can only use the summary statistics for the project described in the application. If you want to use the results for a new research project, you must fill out a new application.

1. ENIGMA2-CHARGE ICV (Adams, Hieab H H et al. “Novel genetic loci underlying human intracranial volume identified through genome-wide association.” Nature neuroscience vol. 19,12 (2016): 1569-1582. doi:10.1038/nn.4398 [LINK])

2. ENIGMA2-CHARGE Hippocampal Volume (Hibar, Derrek P et al. “Novel genetic loci associated with hippocampal volume.” Nature communications vol. 8 13624. 18 Jan. 2017, doi:10.1038/ncomms13624 [LINK])

3. ENIGMA2-CHARGE Subcortical (Satizabal, Claudia L et al. “Genetic architecture of subcortical brain structures in 38,851 individuals.” Nature genetics vol. 51,11 (2019): 1624-1636. doi:10.1038/s41588-019-0511-y. [LINK])

Please indicate for which study you would like the results by filling out this short application form. We will review your application within 5 business days. After vetting your application, we will send an email with instructions for downloading the data.


Thank you, 
The ENIGMA & CHARGE teams
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Email *
First Name *
Last Name *
Institution *
Country *
Proposed research (please provide details) *
Provide a short description of your research. It must include the phenotypes that will be used in your study in relation to the ENIGMA-CHARGE GWAS data you request. Please avoid abbreviations.

Note that due to IRB restrictions we are required to review the aims of analyses using these results. You may be asked to provide further information if your project seeks to use these results in projects involving intelligence, social outcomes such as income, or a behavioral or addiction related trait such as alcoholism. The ENIGMA team will contact you directly should we need more information.
Available summary statistics datasets: Which summary statistics do you want to apply for in this application? Please indicate below.

1. ENIGMA2-CHARGE ICV (Adams, Hieab H H et al. “Novel genetic loci underlying human intracranial volume identified through genome-wide association.” Nature neuroscience vol. 19,12 (2016): 1569-1582. doi:10.1038/nn.4398 [LINK])

2. ENIGMA2-CHARGE Hippocampal Volume (Hibar, Derrek P et al. “Novel genetic loci associated with hippocampal volume.” Nature communications vol. 8 13624. 18 Jan. 2017, doi:10.1038/ncomms13624 [LINK])

3. ENIGMA2-CHARGE Subcortical (Satizabal, Claudia L et al. “Genetic architecture of subcortical brain structures in 38,851 individuals.” Nature genetics vol. 51,11 (2019): 1624-1636. doi:10.1038/s41588-019-0511-y. [LINK])

Two sets of files are available for the ENIGMA2-CHARGE Subcortical sum stats. Select the appropriate set depending on the goals of your project. If you have questions about this, please consult README.docx and do not hesitate to contact us (satizabal@uthscsa.edu):

3a. RESTRICTED USE: Include summary statistics derived from the meta-analysis of all European samples, as it appears on the manuscript. These can be used with the proviso that these summary data SHOULD NOT be used for research into the genetics of intelligence, education, social outcomes such as income, or potentially sensitive behavioral traits such as alcohol or drug addictions.

3b. UNRESTRICTED USE: these include summary statistics derived from the meta-analysis of European samples and the same SNPs present in the “restricted” files, but excluding the following cohorts: AGES, ARIC, CHS, and FHS. Therefore, these results have slightly smaller sample sizes. There are no provisos on the data use of these summary statistics.
1. ENIGMA2-CHARGE ICV (Adams et al 2016)
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2. ENIGMA2-CHARGE Hippocampal Volume (Hibar et al 2017)
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3a. ENIGMA2-CHARGE Subcortical RESTRICTED USE (Satizabal et al 2019)
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3b. ENIGMA2-CHARGE Subcortical UNRESTRICTED USE (Satizabal et al 2019)
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Data usage agreement for all data applied for *
By submitting this form and clicking "I agree" below, you acknowledge that these data will be used only for non-commercial research purposes; that the research you are doing is in compliance with all applicable laws, regulations and institutional policies regarding human subjects and genetics research; that secondary distribution of the data is prohibited and that you will cite the appropriate publication in any communications or publications arising directly or indirectly from these data. Further, the data are provided as-is and without warranty.
A copy of your responses will be emailed to the address you provided.
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