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KCIAPM slide seminar, February 15, 2020
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Case 1) 73 year old female, Itching over the vulva. Known case of diabetes and hypertension.
Link to whole slide image:
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Username - KCIAPMADL2020
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Case 1 Diagnosis
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Case 2) 44 year old female , right adnexal mass with ? metastatic deposits in sigmoid mesentry
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Case 2 Diagnosis
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Case 3) 47 year old female soft tissue swelling over the chin. Received 6 stained slides for opinion
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Username - KCIAPMADL2020
Password - KCIAPMADL2020
Case 3 Diagnosis
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Case 4) 26 year old male, soft tissue swelling over the left ankle joint.
Link to whole slide image:
http://mrpmetvector.in/
Username - KCIAPMADL2020
Password - KCIAPMADL2020
Case 4 Diagnosis
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Case 5) 45 year old male, right adrenal tumor.
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Username - KCIAPMADL2020
Password - KCIAPMADL2020
Case 5 Diagnosis
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Case 6) 10 years female presenting with fever, generalized weakness and mild cognitive impairment.
CBC data
RBC histogram
WBC scatterplots
Peripheral smear
Hb Electrophoresis
Direct Coombs test
Case 6 Interpretation and diagnosis
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Case 7) A 48 year old gentleman with massive splenomegaly, Hb - 13.9 g/dL, WBC - 25,000 and platelet count - 5.5 lakhs .
Link to whole slide image:
http://mrpmetvector.in/
Username - KCIAPMADL2020
Password - KCIAPMADL2020
Peripheral smear
Case 7 Interpretation and diagnosis
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Case 8) A woman in her mid‐30s presented with unexplained splenomegaly (15 cm in greatest dimension by ultrasound scan). Her hemoglobin was 13.8 g/L. Her platelet count was initially 552 × 109/L and remained relatively steady over the following 5 years ranging between 422 and 552 × 109/L. Her white cell count and neutrophil count was only minimally increased on intermittent occasions during these years.
Link to whole slide image:
http://mrpmetvector.in/
Username - KCIAPMADL2020
Password - KCIAPMADL2020
Aspirate images
Aspirate images
Case 8 Interpretation and diagnosis
Your answer
Case 9) 19 year-old boy with generalized lymphadenopathy and splenomegaly. Clinical findings are in favour of acute lymphoblastic leukemia. Hb – 10g/dl, WBC – 13000/ul, Blasts – 65%, Platelet 43000/ul.
Bone marrow morphology - Cell population 1
Bone marrow morphology - Cell population 2
Bone marrow morphology - Cell population 3
Flow cytometry - CD45-SSC gating plot
Flow cytometry - Population 1 (MPO weak +)
Flow cytometry - Population 2
Case 9 Interpretation and diagnosis. What is the probable genetic abnormality?
Your answer
Case 10) 33 year-old gentleman with retroperitoneal mass. Suspected Acute Leukemia
Flow cytometry showed cells positive for CD13, CD33, CD117, HLADR, CD34, MPO and CD19(moderate).
CBC parameters
Peripheral smear
Peripheral smear
Peripheral smear
Bone marrow
Bone marrow
Bone marrow
Bone marrow
Bone marrow
Case 10 Interpretation and diagnosis. What is the probable genetic abnormality?
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